Science News

Nicotinamide protects hepatocytes from palmitate-induced cell death


Researchers from the University of Illinois at Chicago, Zhejiang Chinese Medical University, and Harbin Medical University in China examined the anti-lipotoxic effect of nicotinamide. The results of their study were published in the journal Nutrition Research.

  • Lipotoxicity induced by saturated fatty acids contributes to the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism behind this remains unclear.
  • Palmitate is the most abundant saturated fatty acid in the circulation and a major lipotoxic inducer.
  • Research suggests that autophagy induction is protective against palmitate-induced cell death in a variety of cell types, including hepatocytes.
  • The researchers previously reported that nicotinamide, which is the amide form of vitamin B3 and a dietary supplement, can give hepatocytes resistance against palmitate-induced endoplasmic reticulum stress.
  • In this study, they found that nicotinamide supplementation protected hepatocytes against palmitate-induced cell death by activating autophagy in hepatocytes.
  • They also discovered that autophagy induction is responsible for nicotinamide’s anti-lipotoxic effect.
  • Furthermore, their study demonstrated that the inhibition of sirtuin 1 (SIRT1) weakened autophagy induction in response to nicotinamide supplementation and repealed the anti-lipotoxic effect conferred by nicotinamide supplementation.
  • Their findings suggested that nicotinamide can protect against palmitate-induced liver toxicity via SIRT1-dependent autophagy induction.

Based on these results, the researchers concluded that nicotinamide supplementation represents a therapeutic choice for NAFLD.

For more studies on natural treatments for liver diseases, visit AlternativeMedicine.news.

Journal Reference:

Shen C, Dou X, Ma Y, Ma W, Li S, Song Z. NICOTINAMIDE PROTECTS HEPATOCYTES AGAINST PALMITATE-INDUCED LIPOTOXICITY VIA SIRT1-DEPENDENT AUTOPHAGY INDUCTION. Nutrition Research. April 2017;40:40-47. DOI: 10.1016/j.nutres.2017.03.005



Comments
comments powered by Disqus

RECENT NEWS & ARTICLES